Under what circumstances can a Substitute Statement be submitted according to USPTO guidelines?

The submission of a Substitute Statement is specifically allowed under USPTO guidelines when the original inventor is unable to execute the application due to certain conditions such as being deceased, legally insane, or refusing to execute the application. In these situations, the USPTO permits a substitute statement from another individual who can confirm the relevant facts of the invention. This provision ensures that the application process can continue even when the original inventor is not in a position to act on it, thereby promoting efficiency and fairness in the patent system.

The other choices do not meet the criteria established by USPTO for submitting a Substitute Statement. For instance, relocating outside the country or changing a legal name do not constitute a valid reason for submitting a Substitute Statement, as these situations do not affect an inventor's capability to execute or assign their rights. Similarly, simply being uninterested in the application does not qualify as a legitimate reason for submitting a Substitute Statement, as the inventor still retains the right and obligation to their intellectual property unless they have formally indicated otherwise.